In adults with uncontrolled type 2 diabetes who initially declined insulin versus those who initially accepted, median time to an HbA1c level below 7.0% was 50 months versus 38 months.
Patients with diabetes and mild-to-moderate cardiomyopathy had higher mortality risk than nondiabetic patients with severe cardiomyopathy, suggesting that they may benefit from implantable cardioverter defibrillators, according to the study authors.
While both procedures were associated with high rates of type 2 diabetes remission, the rate of remission five years after surgery was about 10% higher in patients who had gastric bypass than in those who had sleeve gastrectomy.
The data suggest that renoprotection from sodium-glucose cotransporter-2 (SGLT-2) inhibitors may not require the presence of diabetes or albuminuria and may be effective even in patients with worse renal function, an ACP Journal Club commentary said.
In type 2 diabetes, early metformin plus vildagliptin reduced treatment failure vs a stepwise approach
Despite this study's findings, clinicians should continue to follow guidelines and use metformin as the first-line drug intervention, then select from other drug classes when there is a compelling indication, advised an ACP Journal Club commentary.