A post hoc analysis found that patients with baseline systolic blood pressure (BP) <120 mm Hg or >160 mm Hg or follow-up BP <130 mm Hg had a significantly increased risk for a composite outcome of death from cardiovascular (CV) causes, nonfatal myocardial infarction, and nonfatal stroke.
Intensive treatment consisted of whole-mouth subgingival scaling, surgical periodontal therapy if patients practiced good oral hygiene or dental cleaning if they did not, and supportive periodontal therapy every three months until the end of the study.
The findings may reassure prescribers of dipeptidyl peptidase-4 inhibitors that the drug class does not significantly increase the risk of adverse pancreatic outcomes compared with other second-line therapies, study authors said.
Metformin use was linked to hospitalization for acidosis at 6 y only in patients with eGFR <30 mL/min/1.73 m2
The results are in accordance with guidelines and regulatory policy recommendations that have extended use of metformin to individuals with mild to moderate kidney impairment, an ACP Journal Club commentary said.