Current Issue


Effects of early, intensive glycemic control endure for decades, UKPDS data show

Twenty-four years after beginning intensive therapy with a sulfonylurea, insulin, or metformin in the United Kingdom Prospective Diabetes Study (UKPDS), type 2 diabetes patients had significant reductions in mortality compared with patients getting conventional glycemic control.

Coaching may improve diabetes clinical outcomes in real-world primary care settings

A primary care program with health coaching by medical assistants resulted in significantly greater improvements in HbA1c levels than usual care in a trial of high-risk type 2 diabetes patients at two U.S. centers.

Jinlida granules may reduce diabetes risk in patients with impaired glucose tolerance

A Chinese herbal compound was found to significantly lower blood glucose and lipid levels and reduce waist circumference over two years of follow-up compared to placebo, a randomized controlled trial in China found.

MKSAP quiz: Burning pain in feet

This month's quiz asks readers to evaluate a 55-year-old man with type 2 diabetes and burning pain in both feet.

Spotlight on hypoglycemia in older patients

One recent study highlighted the problem of physical food insecurity and another identified predictors of impaired hypoglycemia awareness, both in older diabetes patients. A review suggested varying continuous glucose monitoring targets for older patients by their health status.

Latest Beyond the Guidelines, In the Clinic target diabetes

An endocrinologist and a nephrologist discuss appropriate care for type 2 diabetes and chronic kidney disease, and the evidence supporting type 2 diabetes prevention and treatment are reviewed.

SGLT-2 inhibitors more effective than sulfonylureas, DPP-4 inhibitors as second-line therapy

Patients with type 2 diabetes who added a sodium-glucose cotransporter-2 (SGLT-2) inhibitor to metformin had greater reductions in HbA1c level and body mass at one year than those who added a sulfonylurea or dipeptidyl peptidase-4 (DPP-4) inhibitor, a U.K. study found.

Early mobilization associated with worse outcomes in ICU patients with diabetes

Patients with diabetes in the ICU who received minimized sedation and early physiotherapy were at higher risk for death at 180 days than those who did not, a recent study found.

Continuing metformin linked with lower risk of hospital-acquired complications

Patients who continued metformin upon admission had a lower likelihood of in-hospital complications than matched controls without diabetes, while diabetic patients who discontinued the drug during hospitalization had higher risk than matched controls.

Two case reports describe complications in patients with diabetes

One case report described a type 1 diabetes patient with disseminated mucormycosis with rhinocerebral and pulmonary involvement, while the other reported a case of euglycemic diabetic ketoacidosis related to semaglutide.

FDA advisors vote against weekly insulin for type 1 diabetes

In other diabetes-related actions, the FDA recently authorized marketing of an app for automated insulin delivery and warned about software issues with an existing app and insulin pump.