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ACP Journal Club: SGLT-2 inhibitors reduce adverse renal and CV outcomes in patients with or without diabetes

The results of this meta-analysis of sodium-glucose cotransporter-2 (SGLT-2) inhibitors highlight the opportunity for internists, nephrologists, endocrinologists, and cardiologists to collaborate to expand use of the drug class, an ACP Journal Club commentary said.
https://diabetes.acponline.org/archives/2023/03/10/7.htm
10 Mar 2023

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ACP Diabetes Monthly delivers a monthly summary of news about diabetes, including the latest research, clinical guidelines, and FDA drug actions.
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Social, medical intervention improved glycemic control in rural patients with diabetes

A population health team assessed patients' medical, behavioral, and social needs with annual health risk assessments and partnered with community organizations to improve their access to food, transportation, and medicine.
https://diabetes.acponline.org/archives/2023/03/10/3.htm
10 Mar 2023

Overnight glucose associated with next-day functioning in adults with type 1 diabetes

More variation in overnight glucose levels and time spent above and below glucose targets were associated with adverse changes in measures of next-day function, including attention, sedentary time, and engagement in demanding activities, a study found.
https://diabetes.acponline.org/archives/2023/03/10/2.htm
10 Mar 2023

Insulin prices drop, may spur long-term trend

A major manufacturer announced a cut in the prices of its insulins and instituted a $35 out-of-pocket monthly cap for commercially insured patients.
https://diabetes.acponline.org/archives/2023/03/10/1.htm
10 Mar 2023

Report and study highlight risk of heart failure in patients with diabetes

The American Diabetes Association made recommendations on diagnosing and treating heart failure in patients with diabetes, and a study found increased risk of progression to clinical heart failure in those with an HbA1c level of 7% or above.
https://diabetes.acponline.org/archives/2022/06/10/1.htm
10 Jun 2022

Vitamin D may reduce risk of progression to diabetes from prediabetes

In adults with prediabetes, high-dose vitamin D was associated with a 12% to 15% reduced risk for diabetes compared with placebo, a systematic review and meta-analysis found, but an editorial cautioned about the uncertain risk of adverse effects.
https://diabetes.acponline.org/archives/2023/02/10/3.htm
10 Feb 2023

HbA1c at diagnosis may predict metformin failure, study finds

A model that included baseline HbA1c level, age, sex, and race/ethnicity had high discrimination for predicting failure risk, with the strongest association seen for HbA1c.
https://diabetes.acponline.org/archives/2023/01/13/2.htm
13 Jan 2023

SGLT-2 inhibitors reduce cardiac events, mortality compared to DPP-4 inhibitors

Sodium-glucose cotransporter-2 (SGLT-2) inhibitors were associated with lower risk of cardiovascular events compared to dipeptidyl peptidase-4 (DPP-4) inhibitors but higher risk of genital infections and diabetic ketoacidosis, a retrospective study found.
https://diabetes.acponline.org/archives/2023/02/10/1.htm
10 Feb 2023

Metformin during pregnancy not associated with adiposity in children

A follow-up study of a randomized trial of women with type 2 diabetes during pregnancy found that scores for body mass index were similar up to age 24 months in children who were and were not exposed to metformin in utero.
https://diabetes.acponline.org/archives/2023/02/10/2.htm
10 Feb 2023

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