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Tirzepatide may improve glycemic control when added to insulin glargine in type 2 diabetes

An industry-sponsored phase 3 trial found statistically significant improvements in HbA1c level among patients with type 2 diabetes who had inadequate glycemic control on insulin glargine and were randomly assigned to subcutaneous tirzepatide once weekly versus placebo.
https://diabetes.acponline.org/archives/2022/02/11/1.htm
11 Feb 2022

Study finds long-term reductions in cardiovascular risk factors with SGLT-2 inhibitors

While the meta-analysis also found durable reductions in macrovascular complications and mortality with sodium-glucose cotransporter-2 (SGLT-2) inhibitors versus placebo, there were insufficient data comparing the drug class to other antihyperglycemic medications.
https://diabetes.acponline.org/archives/2021/12/10/2.htm
10 Dec 2021

Adults with diabetes more likely to report mental stress during the COVID-19 pandemic

An online survey of U.S. adults in mid-2020, most of whom were White women, found that those with diabetes were less likely to report resilience and more likely to experience depression than adults without diabetes.
https://diabetes.acponline.org/archives/2021/12/10/3.htm
10 Dec 2021

Neurologists update guideline on treatment of painful diabetic neuropathy

The updated guideline from the American Academy of Neurology supports offering tricyclic antidepressants, serotonin-norepinephrine reuptake inhibitors, gabapentinoids, and/or sodium channel blockers to reduce pain from diabetic neuropathy.
https://diabetes.acponline.org/archives/2022/01/14/1.htm
14 Jan 2022

Spotlight on dementia and glycemic control

Prediabetes and diabetes were associated with development of dementia in a South Korean study, and poorly controlled diabetes was tied to increased risk of incident cognitive impairment or progression to dementia in a Swedish study.
https://diabetes.acponline.org/archives/2021/11/12/5.htm
12 Nov 2021

No long-term disruption of glycemic control seen after COVID-19, study finds

The authors of a small Italian study of hospitalized COVID-19 patients speculated that reversible transient factors, such as inflammation-induced insulin resistance, may cause the hyperglycemia that occurs in some patients with and without diabetes during infection.
https://diabetes.acponline.org/archives/2021/11/12/2.htm
12 Nov 2021

Rates of hypoglycemic, hyperglycemic crises high in patients with diabetes and ESKD

The results of a retrospective study of U.S. data in patients with both diabetes and end-stage kidney disease (ESKD) indicate that current glycemic monitoring and treatment in this population are suboptimal, the authors said.
https://diabetes.acponline.org/archives/2021/11/12/3.htm
12 Nov 2021

Hospitalizations for diabetes complications fell, were replaced by other causes

An analysis of excess hospitalizations among people with diabetes in England from 2003 to 2018 found that diabetes caused fewer of their hospital stays, with respiratory disease and cancer becoming more predominant diagnoses.
https://diabetes.acponline.org/archives/2021/12/10/1.htm
10 Dec 2021

Manufacturer's trials find positive results for combo drug for type 2 diabetes

Tirzepatide, a not-yet-approved dual glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonist, was tested against placebo and semaglutide in recent studies.
https://diabetes.acponline.org/archives/2021/07/09/3.htm
9 Jul 2021

Nearly 5% of adults diagnosed with type 2 diabetes in Scotland were in remission in 2019

Compared with people who did not achieve remission, those in remission tended to be older, to have a lower HbA1c level at diagnosis, to have never taken any glucose-lowering medication, to have lost weight since diabetes diagnosis, and to have had bariatric surgery.
https://diabetes.acponline.org/archives/2021/11/12/1.htm
12 Nov 2021

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