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Studies find link between metformin and reduced COVID-19 mortality, mixed results for DPP-4 inhibitors

Prior metformin use was associated with a threefold decrease in mortality from COVID-19 in one study of patients with type 2 diabetes, while three other studies found mixed results on whether dipeptidyl peptidase-4 (DPP-4) inhibitors affect COVID-19 outcomes.
https://diabetes.acponline.org/archives/2021/02/12/2.htm
12 Feb 2021

Most cases of prediabetes in older adults did not progress to diabetes, study finds

A cohort study of older adults found a high prevalence of prediabetes, but during more than six years of follow-up, death or regression to normoglycemia was more common than progression to diabetes.
https://diabetes.acponline.org/archives/2021/02/12/1.htm
12 Feb 2021

Biomarker score predicts heart failure risk with diabetes and prediabetes

The score, which was based on cardiac troponin, N-terminal pro-B-type natriuretic peptide, C-reactive protein, and electrocardiography, could be used to target specific therapies to the highest-risk patients, study authors said.
https://diabetes.acponline.org/archives/2021/01/08/3.htm
8 Jan 2021

Surgical, drug treatments have similar outcomes in patients with vitreous hemorrhage from proliferative diabetic retinopathy

A randomized trial found equivalent improvements in visual acuity at two years with either therapy but identified some differences in outcomes that could help patients and clinicians choose a treatment method.
https://diabetes.acponline.org/archives/2021/01/08/2.htm
8 Jan 2021

Intermittent fasting may be effective weight loss strategy in patients with type 2 diabetes

A systematic review and meta-analysis of seven studies found that intermittent fasting induced a greater decrease in body weight compared to regular diet but was not associated with any greater reduction in HbA1c levels.
https://diabetes.acponline.org/archives/2021/01/08/1.htm
8 Jan 2021

Patients with type 2 diabetes and all risk factors controlled still have increased CVD risk

Risk factor control was more strongly associated with mortality risk among patients with cardiorenal disease than those without, according to a retrospective British study.
https://diabetes.acponline.org/archives/2020/12/11/3.htm
11 Dec 2020

Balanced crystalloids may be preferred for acute resolution of diabetic ketoacidosis

A small subgroup analysis of two randomized trials found that median time to resolution of diabetic ketoacidosis was 13 hours in patients who received balanced crystalloids versus nearly 17 hours in those who received saline.
https://diabetes.acponline.org/archives/2020/12/11/2.htm
11 Dec 2020

Diabetes remission after bariatric surgery may be more likely in younger patients with shorter disease duration

Long-term results from the Longitudinal Assessment of Bariatric Surgery suggested that diabetes remission is more likely after bariatric surgery performed soon after diagnosis, when diabetes medication burden is low and beta-cell function is preserved, study authors noted.
https://diabetes.acponline.org/archives/2020/12/11/1.htm
11 Dec 2020

Recent KDIGO guideline focused on patients with diabetes and kidney disease

A new summary of the guideline from Kidney Disease: Improving Global Outcomes (KDIGO) highlights important points for clinicians, including recommendations about prescribing of diabetes medications.
https://diabetes.acponline.org/archives/2020/11/13/7.htm
13 Nov 2020

In type 2 diabetes patients, lower LDL cholesterol levels after PCI associated with better outcomes

A pooled analysis of three randomized clinical trials found reductions in major adverse cardiac or cerebrovascular events after percutaneous coronary intervention (PCI) at 3.9-year follow-up only in patients with low-density lipoprotein (LDL) cholesterol levels below 70 mg/dL at one year.
https://diabetes.acponline.org/archives/2020/11/13/3.htm
13 Nov 2020

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