In overweight or obese patients with diabetes, a lifestyle intervention increased weight loss at 8 years
Receiving an intensive lifestyle intervention (ILI) rather than traditional diabetes support and education (DSE) increased weight loss in about 5,000 middle-aged adults with type 2 diabetes.
11 Jul 2014
In newly diagnosed type 2 diabetes mellitus, a Mediterranean diet (vs. a low-fat diet) delayed start of glucose-lowering drugs
Patients who were randomized to a low-carbohydrate Mediterranean diet shortly after type 2 diabetes diagnosis delayed their need for medication compared to those put on a low-fat diet in an Italian trial.
10 Oct 2014
Adding lisinopril to losartan increased hyperkalemia and acute kidney injury in type 2 diabetes and proteinuria
In a trial of more than 1,000 diabetic patients with proteinuria, adding an ACE inhibitor to an ARB didn't improve estimated glomerular filtration rate and increased risk for hyperkalemia and acute kidney injury, so the trial was halted early.
9 May 2014
A review of 3 randomized controlled trials found that surgical treatment increased weight loss and improved diabetes-related outcomes more than nonsurgical treatment in moderately obese patients.
8 Nov 2013
Review: Bariatric surgery increases weight loss and diabetes remission more than nonsurgical treatment
A meta-analysis of 11 randomized, controlled trials found that bariatric surgery improved several health and diabetes outcomes more than nonsurgical treatment.
14 Feb 2014
Review: In type 1 or type 2 diabetes, group medical visits improve HbA1c levels compared with usual care
A meta-analysis of 13 randomized, controlled trials of adults with type 1 or type 2 diabetes found that group medical visits improved HbA1c levels but not the other factors studied, which included blood pressure, body mass index, weight, cholesterol, triglycerides, and quality of life.
14 Mar 2014
A lifestyle intervention did not reduce cardiovascular outcomes in overweight or obese patients with type 2 diabetes
The Look AHEAD trial randomized more than 5,000 overweight and obese type 2 diabetics to intensive lifestyle intervention or diabetes support and education and found that the intensive group reduced several risk factors, but not the primary outcome.
8 Nov 2013
A meta-analysis included 67 randomized controlled trials comparing dipeptidyl peptidase-4 (DPP-4) inhibitors to placebo or other oral antidiabetic agents.
10 May 2013
A meta-analysis of dipeptidyl peptidase-4 inhibitors showed no increase in pancreatic adverse events, while a trial of saxagliptin found no effect on the overall rate of cardiovascular events.
14 Feb 2014
Patients with type 1 diabetes and documented nocturnal hypoglycemia who were randomized to receive sensor-enhanced insulin pump therapy with a threshold-suspend feature had reduced nocturnal hypoglycemia and no difference in glycated hemoglobin levels compared to those on sensor-augmented insulin pump therapy alone, a recent study found.
11 Oct 2013