In insulin-treated type 1 diabetes, canagliflozin increased diabetic ketoacidosis | ACP Diabetes Monthly
Taking canagliflozin, at a dose of either 100 mg or 300 mg per day, was associated with risk of diabetic ketoacidosis, according to a trial that randomized patients with type 1 diabetes to either of the doses or a placebo.
ACP Diabetes Monthly delivers a monthly summary of news about diabetes, including the latest research, clinical guidelines, and FDA drug actions.
Bariatric surgery improved HbA1c more than intensive medical therapy in obese patients with uncontrolled type 2 DM | ACP Diabetes Monthly
Longer-term outcomes show that adding Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy to intensive medical therapy enabled more obese, type 2 diabetes patients to maintain glycemic control.
In overweight or obese patients with diabetes, a lifestyle intervention increased weight loss at 8 years | ACP Diabetes Monthly
Receiving an intensive lifestyle intervention (ILI) rather than traditional diabetes support and education (DSE) increased weight loss in about 5,000 middle-aged adults with type 2 diabetes.
Review: In patients with type 2 diabetes who fast, sitagliptin reduces hypoglycemia more than sulfonylurea | ACP Diabetes Monthly
Patients who took sitagliptin were significantly less likely to have hypoglycemia during Ramadan, according to a systematic review.
Review: Type 2 diabetes screening does not reduce mortality but treating dysglycemia delays onset of diabetes | ACP Diabetes Monthly
A systematic evidence review by the U.S. Preventive Services Task Force found no evidence of mortality benefit from screening for diabetes, based on 2 large randomized controlled trials conducted in the United Kingdom.
Some antimicrobials increased admissions and ED visits for hypoglycemia in older users of glipizide or glyburide | ACP Diabetes Monthly
A study of Texas Medicare patients who took either glipizide or glyburide found that those who were also prescribed certain antibiotics had a much higher rate of hypoglycemic events than those taking an antibiotic not expected to interact with
An intensive lifestyle intervention increased remission from type 2 diabetes in overweight adults | ACP Diabetes Monthly
In the randomized, controlled Look AHEAD trial, an intensive lifestyle intervention (ILI) was associated with partial remission of type 2 diabetes when compared with diabetes education and support (DES).
Adding lisinopril to losartan increased hyperkalemia and acute kidney injury in type 2 diabetes and proteinuria | ACP Diabetes Monthly
In a trial of more than 1,000 diabetic patients with proteinuria, adding an ACE inhibitor to an ARB didn't improve estimated glomerular filtration rate and increased risk for hyperkalemia and acute kidney injury, so the trial was halted early.
Liraglutide reduced a composite renal outcome at a median 4 y in patients with type 2 diabetes and high CV risk | ACP Diabetes Monthly
An ACP Journal Club commentary noted that the mechanism by which liraglutide improves renal outcomes is uncertain and that renal benefit was driven by a decrease in the surrogate outcome of macroalbuminuria, with measures of renal impairment