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Update in Endocrinology highlights top diabetes research of 2013

Ten studies from 2013 with potential to change endocrinology practice were summarized in Annals of Internal Medicine's annual Update in Endocrinology, published in the June 3 issue.
https://diabetes.acponline.org/archives/2014/06/13/5.htm
13 Jun 2014

Recent KDIGO guideline focused on patients with diabetes and kidney disease

A new summary of the guideline from Kidney Disease: Improving Global Outcomes (KDIGO) highlights important points for clinicians, including recommendations about prescribing of diabetes medications.
https://diabetes.acponline.org/archives/2020/11/13/7.htm
13 Nov 2020

ADA position statement updates recommendations for diabetic retinopathy

The position statement, an update of one from 2002, outlines the stages of diabetic retinopathy and highlights recommendations on optimal blood glycemic control and lowering blood pressure.
https://diabetes.acponline.org/archives/2017/03/10/1.htm
10 Mar 2017

Studies examine prescribing patterns, access issues with newer diabetes drug classes

Use of tirzepatide, glucagon-like peptide-1 receptor agonists, and sodium-glucose cotransporter-2 inhibitors increased sharply in the U.S. from 2021 to 2023, one study found, while another noted inequities in availability of newer medications for type 2 diabetes.
https://diabetes.acponline.org/archives/2025/05/09/3.htm
9 May 2025

Standard care noninferior to acellular, cellular matrix products for diabetic foot ulcers

Researchers found no clinically significant differences in ulcer healing between the treatment types but found that acellular matrix products were more cost-effective than cellular matrix products and should thus be considered if standard care fails.
https://diabetes.acponline.org/archives/2025/05/09/2.htm
9 May 2025

Alternative measures didn't help in conditions thought to affect accuracy of HbA1c level

Using fructosamine or glycated albumin did not improve overall accuracy of glycemic measurement in an African population overall or in patients with sickle cell trait, anemia, or renal impairment, according to a comparison of these measures with HbA1c level and continuous glucose monitoring.
https://diabetes.acponline.org/archives/2025/05/09/1.htm
9 May 2025

Gastric bypass increased diabetes remission versus sleeve gastrectomy, small trial finds

At five years after gastric bypass, half of patients with type 2 diabetes and obesity had an HbA1c level less than 6%, compared to 20% of those randomized to sleeve gastrectomy, according to a secondary analysis of a Norwegian trial.
https://diabetes.acponline.org/archives/2025/04/11/3.htm
11 Apr 2025

Switching to tirzepatide improves outcomes vs. escalating dulaglutide in type 2 diabetes

An industry-funded randomized trial found that switching to tirzepatide after inadequate response to dulaglutide led to significant additional reductions in HbA1c levels and weight at 40 weeks compared with increasing the dulaglutide dose.
https://diabetes.acponline.org/archives/2025/04/11/2.htm
11 Apr 2025

Older patients have increased hypoglycemia risk soon after beta-blocker initiation

Hypoglycemia risk nearly doubled in the immediate period after initiation of beta-blockers compared with long-standing use, and the risk was higher in patients who were also taking insulin, a Canadian study of older patients with type 2 diabetes found.
https://diabetes.acponline.org/archives/2025/04/11/1.htm
11 Apr 2025

Studies show potential sequelae on diabetic eye from cataract surgery, GLP-1 use

One retrospective study found that progression to proliferative diabetic retinopathy was more likely after cataract surgery, while another showed that a modest increase in the risk of nonarteritic anterior ischemic optic neuropathy may be associated with the glucagon-like peptide-1 (GLP-1) receptor agonist semaglutide.
https://diabetes.acponline.org/archives/2025/03/14/3.htm
14 Mar 2025

One-hour glucose tolerance test accurate, convenient for postpartum assessment

The one-hour test identified dysglycemia in 60 of 70 patients who were also diagnosed by their two-hour glucose value, as well as 96 additional patients, a single-center Canadian study found.
https://diabetes.acponline.org/archives/2025/03/14/2.htm
14 Mar 2025

Model could help select initial glucose-lowering therapy for type 2 diabetes

Age, duration of diabetes, sex, baseline body mass index, and baseline levels of HbA1c, estimated glomerular filtration rate, cholesterol levels, and alanine aminotransferase were used to predict the effectiveness of five classes of diabetes drugs.
https://diabetes.acponline.org/archives/2025/03/14/1.htm
14 Mar 2025

Spotlight on inpatient diabetes care

Recent studies looked at the use of continuous glucose monitoring and metformin in the hospital.
https://diabetes.acponline.org/archives/2025/02/14/5.htm
14 Feb 2025

SGLT-2 inhibitors, GLP-1 receptor agonists lower COPD exacerbation risk

Sodium-glucose cotransporter-2 (SGLT-2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists were associated with significant reductions in severe chronic obstructive pulmonary disease (COPD) exacerbations compared with dipeptidyl peptidase-4 inhibitors, an observational study found.
https://diabetes.acponline.org/archives/2025/02/14/3.htm
14 Feb 2025

Micronutrient deficiencies, especially vitamin D, common in type 2 diabetes

Approximately 45% of patients with type 2 diabetes were deficient in multiple micronutrients, with vitamin D deficiency the most common at approximately 61%, a meta-analysis of 132 studies found.
https://diabetes.acponline.org/archives/2025/02/14/2.htm
14 Feb 2025

GLP-1 receptor agonists show effects on substance disorders, infections

Researchers should examine the effects of glucagon-like peptide 1 (GLP-1) receptor agonists on multiple diseases, according to the authors of a systematic review that looked at 175 health outcomes in patients taking diabetes medications.
https://diabetes.acponline.org/archives/2025/02/14/1.htm
14 Feb 2025

U.K. consensus statement targets potential barriers to CGM use

Primary care teams face a critical need for education, training, and resources such as electronic health record integration to increase use of continuous glucose monitoring (CGM) in type 2 diabetes, an industry-funded consensus statement said.
https://diabetes.acponline.org/archives/2025/01/10/3.htm
10 Jan 2025

Trial supports insulin as first-line treatment for gestational diabetes

Metformin plus glyburide as needed did not meet criteria for noninferiority to insulin on the outcome of the proportion of infants born large for gestational age, a multicenter trial of 820 patients in the Netherlands found.
https://diabetes.acponline.org/archives/2025/01/10/2.htm
10 Jan 2025

ADA releases updated Standards of Care for 2025

The American Diabetes Association (ADA) has added new recommendations on screening for type 1 diabetes, referring for dental care, and addressing female sexual dysfunction, among other topics.
https://diabetes.acponline.org/archives/2025/01/10/1.htm
10 Jan 2025

Inhaled insulin noninferior to usual care, industry trial in type 1 diabetes finds

Patients who began using inhaled insulin were more likely to have an improvement or worsening in their HbA1c level than patients who continued their existing insulin regimens, but overall glycemic control was similar with either strategy, a randomized trial found.
https://diabetes.acponline.org/archives/2024/12/13/3.htm
13 Dec 2024

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