Switching to sulfonylureas from metformin monotherapy may increase risk of cardiovascular, hypoglycemic events
The results suggest that continuing metformin alone and accepting higher HbA1c targets may be preferable to switching to sulfonylureas when considering macrovascular outcomes and hypoglycemia, an accompanying editorial said.
Patients on the intermittent energy restriction diet ate 500 to 600 kcal/d on two nonconsecutive days each week and followed their usual diet on the other days. They were compared to a group eating 1,200 to 1,500 kcal/d.
Preoperative glucose levels may predict postoperative cardiac outcomes regardless of whether patients have diabetes
For patients without diabetes, predictors of myocardial injury after noncardiac surgery included a casual glucose level of more than 6.86 mmol/L (124 mg/dL) and a fasting glucose level of more than 6.41 mmol/L (116 mg/dL).
Although this retrospective cohort study was limited by its observational design and the risk of confounding by indication, the results should help diabetes patients make informed decisions about their treatment options, the authors said.
Review: Evidence is inconclusive on metabolic surgery vs. medical treatment for microvascular complications in T2DM
A meta-analysis from earlier this year that compared the effects of metabolic surgery and medical treatment found 10 studies to include, only three of them randomized controlled trials.
The evidence favors glucagon-like peptide 1 agonists and, particularly, sodium–glucose cotransporter 2 inhibitors for type 2 diabetes, but the benefits in type 1 diabetes remain speculative, said an ACP Journal Club commentary.
The labeling changes for fluoroquinolones will also make the mental health side effects more prominent and more consistent across the drug class.