Current Issue


Intensive BP control associated with worse CV outcomes in type 2 diabetes and recent ACS

A post hoc analysis found that patients with baseline systolic blood pressure (BP) <120 mm Hg or >160 mm Hg or follow-up BP <130 mm Hg had a significantly increased risk for a composite outcome of death from cardiovascular (CV) causes, nonfatal myocardial infarction, and nonfatal stroke.

Trial finds improvement in HbA1c level with intensive periodontal treatment

Intensive treatment consisted of whole-mouth subgingival scaling, surgical periodontal therapy if patients practiced good oral hygiene or dental cleaning if they did not, and supportive periodontal therapy every three months until the end of the study.

Incretin-based drugs not associated with any increase in risk for pancreatic diseases

The findings may reassure prescribers of dipeptidyl peptidase-4 inhibitors that the drug class does not significantly increase the risk of adverse pancreatic outcomes compared with other second-line therapies, study authors said.

MKSAP quiz: Comparing risk factors

This month's quiz asks readers to evaluate a 62-year-old woman's risk for atherosclerotic cardiovascular disease.

Spotlight on depression in diabetes

Recent studies analyzed depression in diabetes, including associated causes of death, the potential benefits of peer support and a plant-based diet, and strategies for screening and treatment.

Metformin use was linked to hospitalization for acidosis at 6 y only in patients with eGFR <30 mL/min/1.73 m2

The results are in accordance with guidelines and regulatory policy recommendations that have extended use of metformin to individuals with mild to moderate kidney impairment, an ACP Journal Club commentary said.