Age, sex, body mass index, peripheral sensory neuropathy, and estimated glomerular filtration rate were the included variables.
Mortality risk increased with worse glycemic control among patients who had had diabetes for less than five years, while a mean HbA1c level between 6.5% to 7.9% was associated with the lowest mortality risk in those who had had the disease longer.
The findings may reassure prescribers of dipeptidyl peptidase-4 inhibitors that the drug class does not significantly increase the risk of adverse pancreatic outcomes compared with other second-line therapies, study authors said.
The studied risk factors were HbA1c level, LDL cholesterol level, presence of albuminuria, smoking status, and blood pressure.
A study conducted in Australia found that general practitioners with specialization in diabetes care and subspecialist-led clinics reduced HbA1c levels by similar amounts in patients with complex type 2 diabetes.
The findings underscore the urgency of early diagnosis of diabetes and the consequences of failing to achieve near-normal glycemia soon after patients are diagnosed, according to the study authors.
In a retrospective observational study, patients with prediabetes were assigned to a risk category for diabetes based on presence and severity of insulin resistance, impaired beta-cell function, and hyperglycemia, then treated accordingly.
Among patients with coronary artery disease, severity and frequency of hypoglycemia were associated with increased levels of high-sensitivity cardiac troponin T, although the association was attenuated in adjusted analyses.
The guideline, developed by the Joint British Diabetes Societies for Inpatient Care, noted that many patients taking insulin will know more about their usual regimen than the medical and nursing staff responsible for their care.
The American Diabetes Association calls for increasing transparency across the entire supply chain, streamlining the approval process for biosimilars, lowering or removing patient cost-sharing, and increasing access to health care coverage for