The results of this study pose the question of whether the increased likelihood of bladder cancer, which is rare, justifies withholding pioglitazone from adults with type 2 diabetes, according to an accompanying editorial.
Incretin-based drugs not associated with greater heart failure hospitalization risk than other drug combos in retrospective study
Researchers compared patients taking dipeptidyl peptidase 4 (DPP-4) inhibitors and glucagon-like peptide 1 (GLP-1) analogues to those taking 2 or more oral antidiabetic drugs.
Researchers used data from the ADVANCE-ON study to develop the AD-ON risk score, a 10-year risk score for the combined endpoint of major cardiovascular disease (CVD) or chronic kidney disease.
Compared to matched controls, patients on metformin monotherapy did not show significant excess mortality during follow-up, but patients on sulfonylurea or insulin monotherapy had higher mortality rates.
The warnings are based on a review finding 73 cases of ketoacidosis in patients with type 1 or type 2 diabetes and 19 cases of life-threatening urosepsis and pyelonephritis.
The industry-funded, double-blind, randomized, controlled trial assigned adult patients with type 2 diabetes who were not taking antihyperglycemic agents before the study to 26 weeks of treatment in 1 of 5 arms.
The population-based prospective cohort analysis of adults who were members of a single U.S. health care delivery system compared CHD risk among those with and without a history of diabetes or CHD.
A “virtual clinic” model involving consultations between diabetes subspecialists and primary care physicians was associated with glycemic improvements in treated patients and controls from the same practices, a British study found.
The authors stated that the impact of prediabetes awareness on the odds of adopting risk-reducing lifestyle factors highlights the special influence of physician input on patient behavior.
Once-weekly glucagon-like peptide 1 (GLP-1) receptor agonists lower HbA1c without increasing body weight, a review found.