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Update in Endocrinology highlights top diabetes research of 2013

Ten studies from 2013 with potential to change endocrinology practice were summarized in Annals of Internal Medicine's annual Update in Endocrinology, published in the June 3 issue.
https://diabetes.acponline.org/archives/2014/06/13/5.htm
13 Jun 2014

Recent KDIGO guideline focused on patients with diabetes and kidney disease

A new summary of the guideline from Kidney Disease: Improving Global Outcomes (KDIGO) highlights important points for clinicians, including recommendations about prescribing of diabetes medications.
https://diabetes.acponline.org/archives/2020/11/13/7.htm
13 Nov 2020

ADA position statement updates recommendations for diabetic retinopathy

The position statement, an update of one from 2002, outlines the stages of diabetic retinopathy and highlights recommendations on optimal blood glycemic control and lowering blood pressure.
https://diabetes.acponline.org/archives/2017/03/10/1.htm
10 Mar 2017

Spotlight on tech engagement strategies

Veterans with diabetes appeared to use telehealth for complex care needs, a telemonitoring intervention for Black patients did not improve glycemic control, and an electronic referral system led patients with prediabetes to participate in prevention programs, recent studies showed.
https://diabetes.acponline.org/archives/2025/10/10/5.htm
10 Oct 2025

Role of weight loss in prediabetes remission examined

Whether patients had remission of prediabetes in response to an intensive lifestyle intervention was not determined by whether they lost weight, a post hoc analysis of a trial in Germany found. Those who achieved remission did have different distribution of their adipose tissue, however.
https://diabetes.acponline.org/archives/2025/10/10/3.htm
10 Oct 2025

Overuse of HbA1c testing may be common in nursing home residents with diabetes

HbA1c levels were tested frequently even in patients not taking medications for their diabetes, those taking medications with low risk for hypoglycemia, and those whose HbA1c levels were in the target range, a Canadian study found.
https://diabetes.acponline.org/archives/2025/10/10/2.htm
10 Oct 2025

Semaglutide discontinuation more common in patients with diabetes plus stroke, CKD

A study of older adults with diabetes who initiated a glucagon-like peptide-1 receptor agonist found that, in the U.S., more than half had discontinued it within a year, with higher discontinuation rates among those with chronic kidney disease (CKD), a history of stroke, or peripheral vascular disease.
https://diabetes.acponline.org/archives/2025/10/10/1.htm
10 Oct 2025

Statins provided primary prevention benefit in younger patients with type 1 diabetes

Researchers used a British database to conduct a target-trial emulation assessing the benefits of statin initiation in type 1 diabetes patients with a mean age of 45 years. They found significant decreases in 10-year risk of all-cause mortality and cardiovascular disease in those who took statins.
https://diabetes.acponline.org/archives/2025/09/12/3.htm
12 Sep 2025

Semaglutide, tirzepatide showed improved outcomes in patients with HF and diabetes

Risk for heart failure (HF) hospitalization or all-cause mortality was more than 40% lower in patients with type 2 diabetes and HF with preserved ejection fraction who took semaglutide or tirzepatide compared to those who took sitagliptin (a placebo proxy), a study found.
https://diabetes.acponline.org/archives/2025/09/12/2.htm
12 Sep 2025

New living guideline offers advice on medications for type 2 diabetes

The risk-stratified recommendations, developed by an international panel for the BMJ Rapid Recommendations series, are intended to help physicians and patients choose among sodium-glucose cotransporter-2 inhibitors, glucagon-like peptide-1 receptor agonists, finerenone, and tirzepatide.
https://diabetes.acponline.org/archives/2025/09/12/1.htm
12 Sep 2025

Mixed findings on associations between tirzepatide and diabetic retinopathy

New-onset proliferative diabetic retinopathy occurred in 1.1% of patients on tirzepatide versus 0.5% of matched controls, but new onset of any retinopathy was less common in patients with diabetes who took tirzepatide and had no retinopathy at baseline, a retrospective study found.
https://diabetes.acponline.org/archives/2025/08/08/3.htm
8 Aug 2025

Type 2 diabetes remission more likely in patients taking fewer medications, study finds

Just 2.9% of more than 556,000 type 2 diabetes patients who did not undergo bariatric surgery achieved remission over three years, and 36.9% of them relapsed before the end of the three-year follow-up, according to analysis of data from six U.S. health systems.
https://diabetes.acponline.org/archives/2025/08/08/2.htm
8 Aug 2025

Guidance offered on handling pregnancy in patients with pre-existing diabetes

A new joint clinical practice guideline from the Endocrine Society and the European Society of Endocrinology suggests screening for pregnancy intent in diabetes patients and addresses use of glucagon-like peptide-1 receptor agonists, insulin, and continuous glucose monitoring before and during pregnancy.
https://diabetes.acponline.org/archives/2025/08/08/1.htm
8 Aug 2025

Fenofibrate cost-effective for preventing diabetic retinopathy progression

In diabetes patients with mild background retinopathy in both eyes or observable background retinopathy or maculopathy in one or both eyes, treatment with fenofibrate reduced the need for any referable diabetic retinopathy or treatment by 4.4% over two years, an analysis of a randomized trial found.
https://diabetes.acponline.org/archives/2025/07/11/3.htm
11 Jul 2025

Mifepristone improved diabetes control in hypercortisolism, industry trial finds

Patients with poorly controlled type 2 diabetes and hypercortisolism assigned to mifepristone versus placebo had lower HbA1c levels and greater reductions in body mass index and waist circumference at 24 weeks, although adverse events were common.
https://diabetes.acponline.org/archives/2025/07/11/2.htm
11 Jul 2025

Semaglutide associated with lower stroke risk than empagliflozin

An analysis of observational data found better outcomes with semaglutide than empagliflozin, particularly in patients younger than age 65 years. Outcomes with dulaglutide were similar to those with empagliflozin.
https://diabetes.acponline.org/archives/2025/07/11/1.htm
11 Jul 2025

Diabetes progression linked with increased risk of kidney cancer

Kidney cancer risk was significantly higher in patients with prolonged duration of diabetes, those with diabetic retinopathy or nephropathy, and those with poor glycemic control, a cohort study in South Korea found.
https://diabetes.acponline.org/archives/2025/06/13/3.htm
13 Jun 2025

Renal outcomes better with finerenone plus empagliflozin in type 2 diabetes and CKD

Patients with type 2 diabetes and chronic kidney disease (CKD) had a greater reduction in urinary albumin-to-creatinine ratio if they took finerenone plus empagliflozin versus either drug alone, an industry trial found.
https://diabetes.acponline.org/archives/2025/06/13/2.htm
13 Jun 2025

ADA consensus report calls for MASLD, liver fibrosis screening in type 2 diabetes

A two-tier system for stratifying patients based on their risk of metabolic dysfunction-associated steatotic liver disease (MASLD) was recommended by the American Diabetes Association (ADA).
https://diabetes.acponline.org/archives/2025/06/13/1.htm
13 Jun 2025

Studies examine prescribing patterns, access issues with newer diabetes drug classes

Use of tirzepatide, glucagon-like peptide-1 receptor agonists, and sodium-glucose cotransporter-2 inhibitors increased sharply in the U.S. from 2021 to 2023, one study found, while another noted inequities in availability of newer medications for type 2 diabetes.
https://diabetes.acponline.org/archives/2025/05/09/3.htm
9 May 2025

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