Current Issue

Risk for new-onset diabetes appears to have increased during COVID-19 pandemic

While the pandemic period was associated with more new cases of type 2 diabetes across subgroups, risk was highest among patients exposed to SARS-CoV-2, a cohort study in Florida found.

Diabetes-related foot ulcers associated with high short-term mortality rates

In patients with a new diabetes-related foot ulcer, mortality rates were 4.2%, 8.2%, and 14.4% at 12, 26, and 52 weeks, and even higher rates were seen with cardiovascular or renal comorbidities or older age, a study in England and Wales found.

Metformin linked with lower delirium risk in older patients with type 2 diabetes

There was a dose-response relationship between metformin and delirium in those ages 65 years and older, with higher cumulative and daily doses of the medication linked with lower delirium risk, a cohort study in Taiwan indicated.

MKSAP quiz: Elevated HbA1c level, loss of energy in older patient

This month's quiz asks readers to evaluate a 71-year-old woman who reports no symptoms other than loss of energy. Her medical history is significant for hypertension, type 2 diabetes mellitus, and dyslipidemia.

Spotlight on liver health in diabetes

A review compared liver outcomes for most classes of diabetes drugs, while a retrospective study looked at glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors head to head. Another study offered a new score for metabolic dysfunction-associated steatotic liver disease.

In adults with metabolic dysfunction, the MAF-5 score predicted risk for liver fibrosis (AUC range, 0.73 to 0.81)

The new Metabolic Dysfunction-Associated Fibrosis 5 (MAF-5) score could potentially identify patients in primary care who are at risk for progressive fibrosis and facilitate interventions and treatment, but it needs to be prospectively validated, an ACP Journal Club commentary said.

Statin therapy alone does not appear to increase diabetes risk in patients with HIV and no other diabetes risk factors

An analysis of data from a randomized trial found that statin treatment affected risk for new-onset diabetes primarily among patients with HIV who had multiple metabolic risk factors.

Recall, expanded indication for different CGMs

Some sensors for the Freestyle Libre 3 continuous glucose monitor (CGM) were recalled, and an interoperable automated glycemic controller was approved for insulin-dependent type 2 diabetes.