Current Issue
Guidance offered on handling pregnancy in patients with pre-existing diabetes
A new joint clinical practice guideline from the Endocrine Society and the European Society of Endocrinology suggests screening for pregnancy intent in diabetes patients and addresses use of glucagon-like peptide-1 receptor agonists, insulin, and continuous glucose monitoring before and during pregnancy.
Type 2 diabetes remission more likely in patients taking fewer medications, study finds
Just 2.9% of more than 556,000 type 2 diabetes patients who did not undergo bariatric surgery achieved remission over three years, and 36.9% of them relapsed before the end of the three-year follow-up, according to analysis of data from six U.S. health systems.
Mixed findings on associations between tirzepatide and diabetic retinopathy
New-onset proliferative diabetic retinopathy occurred in 1.1% of patients on tirzepatide versus 0.5% of matched controls, but new onset of any retinopathy was less common in patients with diabetes who took tirzepatide and had no retinopathy at baseline, a retrospective study found.
MKSAP quiz: Hyperglycemia in the hospital
This month's quiz asks readers to evaluate and manage a 74-year-old man with hyperglycemia. He was hospitalized a few hours earlier for an acute ischemic stroke.
Spotlight on diabetes and sleep
Sleep problems are associated with diabetes distress, one study found, while others showed that snoring while pregnant might indicate higher risk of gestational diabetes but insomnia symptoms do not significantly improve type 2 diabetes risk prediction.
Dementia risk similar with GLP-1 receptor agonists, DPP-4 inhibitors
A target trial emulation that matched Medicare patients who started glucagon-like peptide-1 (GLP-1) receptor agonists or dipeptidyl peptidase-4 (DPP-4) inhibitors did not find a significant difference in their dementia risk.
Canagliflozin safe, tolerable in kids, adolescents, manufacturer study finds
A phase 3 trial found significantly greater reductions in HbA1c levels in children and adolescents 10 years of age and older who were randomized to canagliflozin versus placebo.
In insulin-treated T2D, automated insulin delivery reduced HbA1c without increasing hypoglycemic events vs. usual care at 13 wk
A manufacturer trial showed that automated insulin delivery is safe and effective for improving HbA1c levels in a range of patients with type 2 diabetes, but the technology will require attentiveness and problem solving to troubleshoot, an ACP Journal Club commentary said.
GLP-1s associated with increased risk of GERD
Patients with type 2 diabetes who started a glucagon-like peptide-1 (GLP-1) receptor agonist had a 27% higher risk of gastroesophageal reflux disease (GERD) than those who took a sodium-glucose cotransporter-2 inhibitor, a retrospective study found.
Regular vigorous activity associated with significantly lower risk of mortality in diabetes
Cardiovascular mortality risk was significantly lower in patients with diabetes who engaged in at least 150 minutes of moderate to vigorous exercise per week, whether it was twice a week (“weekend warriors”) or more frequently, according to an analysis of the National Health Interview Survey.
Glucose monitoring receivers recalled
Certain receivers from Dexcom were recalled because their speakers may fail to make an alert sound.