Search results for "From ACP Journal Club"
In T2DM, periconceptional, noninsulin, second-line antidiabetes medications were not linked to major congenital malformations vs. insulin
A new study provides some reassurance to patients who unintentionally become pregnant while taking diabetes drugs but should be interpreted with caution because the number of infants exposed was low and only pregnancies resulting in live births were included, an ACP Journal Club commentary said.
https://diabetes.acponline.org/archives/2024/04/12/7.htm
12 Apr 2024
In higher-risk, statin-intolerant adults with diabetes, bempedoic acid reduced MACE at a median 3 y
An ACP Journal Club commentary noted that it's unknown whether lower-risk and younger statin-intolerant patients would derive the degree of benefit from bempedoic acid found in this study, since the industry-funded trial enrolled only high-risk and older patients.
https://diabetes.acponline.org/archives/2024/04/12/8.htm
12 Apr 2024
In latent autoimmune diabetes in adults, mortality was similar to T2DM but retinopathy was higher at 5.9 y
If confirmed, the findings of different disease trajectories among patients with latent autoimmune diabetes in adults could eventually merit reclassification of the types of diabetes, an ACP Journal Club commentary said.
https://diabetes.acponline.org/archives/2024/01/12/6.htm
12 Jan 2024
In T2DM requiring insulin initiation, icodec titrated with an app safely reduced HbA1c vs. daily basal insulin analogues at 52 wk
An ACP Journal Club commentary cautioned that although a recent industry-funded trial was designed to approximate real-world practice, certain factors may still limit the generalizability of its findings.
https://diabetes.acponline.org/archives/2024/01/12/7.htm
12 Jan 2024
In T2DM with obesity, time-restricted eating increased weight loss and reduced HbA1c level at 6 mo
The small trial comparing time-restricted eating and calorie restriction with control was adequately powered to inform clinical practice, but larger trials with longer follow-up should be done to confirm the results, an ACP Journal Club commentary said.
https://diabetes.acponline.org/archives/2024/02/09/6.htm
9 Feb 2024
In adults with BMI ≥27 kg/m2 and type 2 diabetes, adding tirzepatide to a lifestyle intervention increased weight loss at 72 wk
The new drugs known as “twincretins” represent a major breakthrough for patients with overweight or obesity, prediabetes, or diabetes, but obstacles will include supply, lack of cost-effectiveness evidence, and insurance coverage, an ACP Journal club commentary said.
https://diabetes.acponline.org/archives/2023/11/10/7.htm
10 Nov 2023
In patients with type 2 diabetes or HF, SGLT2 inhibitors reduce gout-related outcomes
The effects of sodium-glucose cotransporter 2 (SGLT2) inhibitors on gout in patients with type 2 diabetes or heart failure (HF) may allow reduced polypharmacy when treatment for gout is also needed, an ACP Journal Club commentary said.
https://diabetes.acponline.org/archives/2023/11/10/6.htm
10 Nov 2023
In T2DM uncontrolled with noninsulin glucose-lowering agents, weekly icodec reduced HbA1c vs. daily degludec at 26 wk
Weekly insulin icodec has shown potential benefit in recent trials, but data on its effects in patients with type 1 diabetes or renal or hepatic failure are still awaited, an ACP Journal Club commentary noted.
https://diabetes.acponline.org/archives/2023/10/13/7.htm
13 Oct 2023
In uncontrolled T2DM treated with a basal-bolus insulin regimen, weekly icodec was noninferior to daily glargine for HbA1c at 26 wk
Weekly insulin injections might be optimal for patients with type 2 diabetes who are already taking weekly glucagon-like peptide 1 receptor agonists and need additional basal insulin, noted an ACP Journal Club commentary.
https://diabetes.acponline.org/archives/2023/08/11/6.htm
11 Aug 2023
In types 1 and 2 diabetes, weekly basal insulin Fc was noninferior to daily insulin degludec for HbA1c at 26 wk
The arrival of once-weekly insulin will undoubtedly be welcomed by patients and clinicians, but the advantages of fewer shots will have to be weighed against less flexibility in dosing of basal insulin, an ACP Journal Club commentary said.
https://diabetes.acponline.org/archives/2023/07/14/7.htm
14 Jul 2023