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Spotlight on diabetes drug class comparisons

A large trial compared insulin, a sulfonylurea, a glucagon-like peptide-1 (GLP-1) receptor agonist, and a dipeptidyl peptidase-4 inhibitor as second-line therapy, while a modeling study considered GLP-1 receptor agonists and sodium-glucose cotransporter-2 inhibitors as first-line agents.
https://diabetes.acponline.org/archives/2022/10/14/5.htm
14 Oct 2022

Younger patients often ration insulin due to cost, study finds

Data from the 2021 National Health Interview Survey indicate that one in five patients younger than age 65 years, who would not be eligible for the $35 monthly Medicare price cap, have skipped or reduced insulin doses or put off buying the drug to save money.
https://diabetes.acponline.org/archives/2023/04/14/3.htm
14 Apr 2023

NSAID use linked to risk of heart failure hospitalization in type 2 diabetes

Danish patients with type 2 diabetes who took prescription NSAIDs had increased risk of first-time heart failure hospitalization, particularly if they were new users of the drugs or age 65 years or older, a recent study found.
https://diabetes.acponline.org/archives/2023/04/14/2.htm
14 Apr 2023

Guaranteeing adequate carbs before postpartum oral glucose tolerance testing may not be necessary

An analysis of data from two prospective studies found no relationship between carbohydrate intake in the day or days before testing and glucose level 120 minutes after oral glucose tolerance testing.
https://diabetes.acponline.org/archives/2023/05/12/1.htm
12 May 2023

Social, medical intervention improved glycemic control in rural patients with diabetes

A population health team assessed patients' medical, behavioral, and social needs with annual health risk assessments and partnered with community organizations to improve their access to food, transportation, and medicine.
https://diabetes.acponline.org/archives/2023/03/10/3.htm
10 Mar 2023

Overnight glucose associated with next-day functioning in adults with type 1 diabetes

More variation in overnight glucose levels and time spent above and below glucose targets were associated with adverse changes in measures of next-day function, including attention, sedentary time, and engagement in demanding activities, a study found.
https://diabetes.acponline.org/archives/2023/03/10/2.htm
10 Mar 2023

ACP Journal Club: SGLT-2 inhibitors reduce adverse renal and CV outcomes in patients with or without diabetes

The results of this meta-analysis of sodium-glucose cotransporter-2 (SGLT-2) inhibitors highlight the opportunity for internists, nephrologists, endocrinologists, and cardiologists to collaborate to expand use of the drug class, an ACP Journal Club commentary said.
https://diabetes.acponline.org/archives/2023/03/10/7.htm
10 Mar 2023

HbA1c at diagnosis may predict metformin failure, study finds

A model that included baseline HbA1c level, age, sex, and race/ethnicity had high discrimination for predicting failure risk, with the strongest association seen for HbA1c.
https://diabetes.acponline.org/archives/2023/01/13/2.htm
13 Jan 2023

Fiber-enriched formula linked to improved health-related quality of life, HbA1c in type 2 diabetes

Participants who consumed prebiotic fiber-enriched nutritional shakes had improved measures of health-related quality of life and reduced HbA1c level at 12 weeks compared to those who consumed placebo shakes, an industry-funded trial found.
https://diabetes.acponline.org/archives/2023/01/13/3.htm
13 Jan 2023

Insulin prices drop, may spur long-term trend

A major manufacturer announced a cut in the prices of its insulins and instituted a $35 out-of-pocket monthly cap for commercially insured patients.
https://diabetes.acponline.org/archives/2023/03/10/1.htm
10 Mar 2023

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