Metformin was associated with a lower risk of mortality than sulfonylureas both overall and in all categories of estimated glomerular filtration rate, the observational study found.
The results highlight the potential benefit of targeting individuals with an elevated one-hour blood glucose level and, if supported by additional evidence, eventually replacing the two-hour test with a one-hour measure, the authors said.
The most important predictors of the trajectory of glucose control were body mass index and levels of HbA1c and triglycerides, according to the study of registry data from the Netherlands.
Lifestyle modification may outperform medications over time for diabetes prevention, meta-analysis finds
Twenty-five people would need to be treated with lifestyle modification to prevent one diabetes case, according to the analysis of randomized clinical trials that evaluated lifestyle modification and medication interventions for diabetes prevention in at-risk adults.